OTHER DEVICES

Wearables and Implantables

Ambulatory electrocardiographic (ECG) monitors are chest-worn devices for free-living cardiac monitoring. Modern monitors collect high-quality single-lead ECG data using two electrodes and are much more convenient, and less invasive than traditionally used Holter monitors. They are water-resistant and can be worn continuously for up to 14 days.

Multiple models of commercial, inexpensive ambulatory ECG monitors were introduced to the market in recent years, resulting in the rapidly growing interest of

researchers.

With a sampling frequency of around 200 Hz, data collected over multiple days can reach hundreds of millions of samples per individual understandably creating computational and logistical challenges in large-scale studies. At the ARC, we use GPU-accelerated signal processing and machine learning algorithms to characterize heart rate variability, diurnal patterns, as well as sympathetic and parasympathetic nervous system function.

Continuous Blood-Glucose Monitors are small devices attached to the body by a skin-safe adhesive with a small needle implanted under the skin, that can collect the blood glucose measurements in a few minute intervals across multiple days at a time. These implantables were originally introduced to aid diabetes treatment and management, and reduce the burden of traditional, fingerstick-based measurements.

While the technology is still maturing, it already creates new and exciting research opportunities allowing for a new level of insight into daily glycemic variability and the quality of glycemic control and it is being widely adopted into large observational studies and clinical trials.